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NSAIDS induced GI mucosal injury
Elucidate the NSAIDS induced GI toxicity?
Upper GI | Small Bowel | Colon |
---|---|---|
GORD
Subepithelial petechial haemorrhage Erosions Ulcers(stomach>Duodenum) Bleeding(stomach=duodenum) Perforation/obstruction |
Ulcers
Strictures Diaphragms Enteropathy |
Colitis
Ulcers Strictures Diverticular bleed or perforation Collagenous colitis Relapse of IBD |
Use of capsule endoscopy has revealed that NSAID plus PPI strategy does not effectively reduce the small bowel lesions that will occur with an NSAID in the small intestine.
12.5% of all GI events which occur with NSAIDs are found in the lower gastrointestinal tract. This proportion of events would not be effectively treated by the NSAID plus PPI strategy.
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