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NSAIDS induced GI mucosal injury

Elucidate the NSAIDS induced GI toxicity?

Upper GI Small Bowel Colon
GORD

Subepithelial petechial haemorrhage

Erosions

Ulcers(stomach>Duodenum)

Bleeding(stomach=duodenum)

Perforation/obstruction

Ulcers

Strictures

Diaphragms

Enteropathy

Colitis

Ulcers

Strictures

Diverticular bleed or perforation

Collagenous colitis

Relapse of IBD

Use of capsule endoscopy has revealed that NSAID plus PPI strategy does not effectively reduce the small bowel lesions that will occur with an NSAID in the small intestine.

12.5% of all GI events which occur with NSAIDs are found in the lower gastrointestinal tract. This proportion of events would not be effectively treated by the NSAID plus PPI strategy.


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